AMAMUS Vet coldPlasma

 

Physical plasma
Physical plasma is the 4th state of aggregation. If gas is energetically charged, plasma occurs.

In nature, plasma occurs in all forms of lightnings. In industry, plasma is utilised for coatings, finishings and for desinfection purposes.

Used on skin, plasme acts

- highly antimicrobial,

- stimulates cell division

- reduces pain as well as itching

 

Scientific background - plasma-medicine
Plasma-medicine emerged during the last 15 years. Few medical sectors received such wide scientific interest as did the field of plasma-medicine. The first professorship for plasma-medicine was established in 2011 in Germany where the two Universities of Göttingen and Greifswald as well as the Fraunhofer and Leibnitz institutes need to be highlighted. 

In the meantime, the technology has been tested by more than 40 renowned universities, clinics and institutes all around the world - among which such well-known names as: North Carolina, Oxford, Cambridge, Osaka, and many more… . Apart from the application for wounds, exzemas, mycoses and viral skin disorders, cold plasma is being/ will be used in cancer research.

 

In 2012, the first consensus paper dealing with the application of cold plasma has been released. Two books independently of each other summarise the current status quo of cold plasma medicine:


                     springer.com
                     uni-med.de

 

Where is cold plasma being used?
Scientifically confirmed scopes of application are:

  • wounds (intraoperative wounds, surgical wounds, wounds with wound healing disorders, infected wounds, general wound aftercare)
  • exzemas (skin irritations, pyodermas, mallenders, sweet itch, inflamated mouth angles, ...)
  • mycoses.

 


It is now general consensus that the coldPlasma technology is an excellent therapy for these 3 indications and shall find more use in these ranges of application.


Antimicrobial effect
An especially important aspect of the treatment via coldPlasma is its antimicrobial effectiveness which has already been proven by Daeschlein against a multitude of pathogenic bacteria and fungi in 2009. The treatment proved to be a simple, very effective and especially highly tolerable therapy. This effect has been tried and tested with positive results numbers of times and is now scientifically beyond dispute. Currently, mainly the very reactive oxygen and nitrogen coumpounds (NO, OH, O3, H2O2 und O) are held responsible for the effective killing of microorganisms.

The second important aspect of cold plasma is the stimulation of cell division and cell regeneration

In his book „Physikalische Plasmatherapie – Theorie und Anwendungspraxis eines neuen Behandlungsverfahrens im Bereich der chronischen Wunden 3 umfassende Studien (Brehmer et al.2014, Isbary et al. 2010 & 2012)", Daeschlein very successfully points out ...

the great advantages of this technology:

  • Simple application
  • high effectiveness
  • lack of downsides
  • lack of side effects

 

Literarture references:

Daeschlein, G., von Woedtke, T., Kindel, E., Brandenburg, R., Weltmann, K. D., Jünger, M. 2009. Antibacterial activity of atmospheric pressure plasma jet (APPJ) against relevant wound pathogens in vitro on simulated wound environment. Plasma Process and Polymers 6:224–30.
Daeschlein, G., Scholz, S., Ahmed, R., Majumdar, A., von Woedtke, T., Haase, H., Niggemeier, M., Kindel, E., Brandenburg, R., Weltmann, K. D., Jünger, M. 2012. Cold plasma is well-tolerated and does not disturb skin barrier or reduce skin moisture. Blackwell Verlag GmbH, Berlin, Journal of the German Society of Dermatology 7(10):509–515.

Daeschlein, G., et al, Plasma Kurrier 1/2014: Stellenwert moderner physikalischer Behandlungsverfahren bei infizierten und kolonisierten Wunden in der Dermatologie
Weltman, Woedtke; Plasma Physics and Controlled Fusion 59(1):014031 · January 2017: Plasma medicine - Current state of research and medical application
Daeschlein, G., von Woedtke, T., Kindel, E., Brandenburg, R., Weltmann, K. D., Jünger, M. 2009. Antibacterial activity of atmospheric pressure plasma jet (APPJ) against relevant wound pathogens in vitro on simulated wound environment. Plasma Process and Polymers 6:224–30.
Daeschlein, G., Scholz, S., Ahmed, R., Majumdar, A., von Woedtke, T., Haase, H., Niggemeier, M., Kindel, E., Brandenburg, R., Weltmann, K. D., Jünger, M. 2012. Cold plasma is well-tolerated and does not disturb skin barrier or reduce skin moisture. Blackwell Verlag GmbH, Berlin, Journal of the German Society of Dermatology 7(10):509–515.
Daeschlein G. et.al.: UNI-MED Verlag AG 2017; Physikalische Plasmatherapie – Theorie und Anwendungspraxis eines neuen Behandlungsverfahrens: S.57-73
Helmke A, Hoffmeister D, Berge F, Emmert S, Laspe P, Mertens N, Vioel W, Weltmann KD (2011) Physical and microbiological characterization of Staphylococcus epidermidis inactivation by dielectric barrier discharge. Plasma Process Polym 8(4): 278-286.
Fridman G, Peddinghaus M, Balasubramanian M et al. (2006) Blood coagulation and living tissue sterilization by floating-electrode dielectric barrier discharge in air. Plasma Chem Plasma Process 27: 425–443.
Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A (20089 Applied plasma medicine. Plasma Process Polym 5: 503–533.
Daeschlein G, Scholz S, ArnoldAet al. (2012) In vitro susceptibility of important skin and wound pathogens against low temperature atmospheric pressure plasma jet (APPJ) and dielectric barrier discharge plasma (DBD). Plasma Process Polym 9: 380–389.
Arndt S, Landthaler M, Zimmermann JL, Unger P, Wacker E, Shimizu T, Li YF, Morfill GE, Bosserhoff AK, Karrer S PLoS One. Effects of cold atmospheric plasma (CAP) on ß-defensins, inflammatory cytokines, and apoptosis-related molecules in keratinocytes in vitro and in vivo. 2015; 10(3):e0120041.
Korolov I, Fazekas B, Szell M, Kemeny L, Kutasi K. The effect of the plasma needle on the human keratinocytes related to the wound healing process. Journal of Physics D-Applied Physics. 2016;49(3):035401.
Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin. Schmidt A, von Woedtke T, Bekeschus S Oxid Med Cell Longev. 2016; 2016():9816072.

Weltman, Woedtke; Plasma Physics and Controlled Fusion 59(1):014031 · January 2017: Plasma medicine - Current state of research and medical application
Effects of cold atmospheric plasma (CAP) on ß-defensins, inflammatory cytokines, and apoptosis-related molecules in keratinocytes in vitro and in vivo. Arndt S, Landthaler M, Zimmermann JL, Unger P, Wacker E, Shimizu T, Li YF, Morfill GE, Bosserhoff AK, Karrer S PLoS One. 2015; 10(3):e0120041.
Korolov I, Fazekas B, Szell M, Kemeny L, Kutasi K. The effect of the plasma needle on the human keratinocytes related to the wound healing process. Journal of Physics D-Applied Physics. 2016;49(3):035401.
Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin. Schmidt A, von Woedtke T, Bekeschus S Oxid Med Cell Longev. 2016; 2016():9816072.